Research Summary

Resarch Support Awarded (2005 – Current)

As Principal Investigator

• 2003-2013 National Institutes of Health, National Cancer Institute. Retrovirus Models of Lymphocyte Transformation and Disease P01CA100730. Principal Investigator. Total Annual Direct Cost $1,369,698. Also, PI of Project 1 and Administrative Core
• 2007-2012 Director, National Institutes of Health, National Center for Research Resources, Mouse Pathobiology: Models Of Human Disease T32 RR07073-01A1. Co-director Dr. T. Rosol) of Training Grant. $1,484,000 Total Direct Costs.
• 2006-2011 Targeted Investment, Ohio State University, Provost Office, "Public Health Preparedness: Emerging Infectious Diseases", (Co-PI with Drs. L. Schlesinger, T. Buckley, K. Lee, R. Brueggermeier, J. Reeves - TIE Steering Committee), $4.8 million Total Direct Costs (~1.1 million to OSU College of Veterinary Medicine).
• 2006-2007 Ohio State University, Comprehensive Cancer Center, Viral Oncogenesis Program, Internal Research Award, "Viral Oncolysis and Heat Shock Induction", (Co-PI with Dr. S. Niewiesk), $10,000 Total Direct Costs.
• 2006-2007 Banfield Trust and OSU Cares Grant, Ohio State University Extension, Community Outreach Grant, "Careers in Veterinary Medicine", 5% Effort, Co-Principal Investigator (Dr. Nong Inpanbutr, College of Veterinary Medicine Co-PI), $20,000 Total Direct Costs.
• 2002-2005 Washington University, "Chemo/Antiretroviral Therapy for HTLV-1 ATLL". Subcontract to R21 Clinical Trial, Phase II Trial of Induction Therapy with EPOCH Chemotherapy and Maintenance, Therapy with Combivir/Interferon for HTLV-1 Associated T-cell non-Hodgkin's Lymphoma, A Multicenter Trial of the AIDS Malignancy Consortium. $28,000 Total Direct Costs.
• 2002-2005 National Institutes of Health, HIV-AIDS and Related Illnesses Research Collaboration NIH/Fogarty International Center, "Studies of p30 II and p13 II in HTLV-1 infection". R03 TW005705-01A1, Principal Investigator, $ 96,000 Total Direct Costs.
• 1999-2005 National Institutes of Health, National Center for Research Resources, "Animal Models of Molecular Pathogenesis of HTLV-1", R01 RR14324-01, Principal Investigator, $1,243,000 Total Direct Costs.

As Co-Investigator or Mentor

• 2007-2012 Sponsor, National Institutes of Health, National Center for Research Resources,; K01 RR023965. Developing new mouse models of ATL for use in trials of targeted therapies . Dr. Bevin Zimmerman, Special Emphasis Research Career Award, $634,500 Total Direct Costs.
• 2004-2008 Sponsor, Mr. Rashade Haynes, National Institute of Health Minority Supplemental Award $170,019 Total Costs
• 2005-2007 National Institutes of Health, National Cancer Institute. Role of viral HBZ in HTLV-1 replication. R21 AI064440. 5 % Effort, Co-Investigator (Dr. P. Green PI. College of Veterinary Medicine), $275,000 Total Direct Costs.
• 2003-2008 National Institutes of Health, National Cancer Institute. Retrovirus Models of Lymphocyte Transformation and Disease P01CA100730. Principal Investigator. Total Annual Direct Cost $1,369,698. Also,Co-Investigator of Project 2, 3, 4, & 5.  

As Sponsor for Graduate/Postdoctoral Training Awards or Director for Training Grants

• 2007-2012 Director, National Institutes of Health, National Center for Research Resources, Mouse Pathobiology: Models Of Human Disease T32 RR07073-01A1. $1,484,000 Total Direct Costs.
• 2007-2012 Sponsor, National Institutes of Health, National Center for Research Resources,; K01 RR023965. Developing new mouse models of ATL for use in trials of targeted therapies. Dr. Bevin Zimmerman, Special Emphasis Research Career Award, $634,500 Total Direct Costs.
• 2007-2008 Principal Investigator, Merck-Merial Veterinary Scholars Grant, Funded 4 veterinary students over 2 summers for summer research projects, Total Award $20,700.
• 2004-2008 Sponsor, Mr. Rashade Haynes, National Institute of Health Minority Supplemental Award $170,019 Total Costs
• 2004-2005 Sponsor, The Glen Barber Fund, College of Veterinary Medicine, Dr. Seung-jae Kim, Graduate Student Awardee, $24,500/year
• 2003-2006 Principal Investigator and Director, National Institutes of Health, National Center for Research Resources, Research Training for Veterinary Students T32 RR17505. Director of Training Grant. $211,180 Total Direct Costs.
• 2002-2007 Co-Director, National Institutes of Health, National Center for Research Resources, Mouse Pathobiology: Models Of Human Disease T32 RR07073-01A1. Co-director (with Dr. Tom Rosol) of Training Grant. $1,200,000 Total Direct Costs.
• 2003-2006 Co-Director, United States Department of Agriculture Training Contract for Veterinary Pathologists in Biodefense and Emerging Diseases. In collaboration with the Ohio Department of Agriculture (Dr. Beverly Byrum). $105,000 Total Direct Costs.
• 2003-2005 Sponsor, The Glen Barber Fund, College of Veterinary Medicine, Dr. Hajime Hiraragi, Graduate Student Awardee, $24,500/year

Training Summary

Dr. Michael Lairmore, DVM, PhD is Director of an NIH T-32 Training Grant in Animal Models of Human Disease: Mouse Pathobiology funded from 2007-2012. He is highly devoted to graduate education and is extremely active in this role as mentor for veterinarians seeking research training. In 1990 he joined OSU after his post doctoral training at the Centers for Disease Control, Atlanta, GA where he was a Section Chief. At OSU he was promoted to Associate Professor with tenure in 1994. In 1995, he was jointly appointed as a member of the Department of Medical Microbiology and Immunology in the OSU, College of Medicine. In 1996, he successfully completed requirements for Diplomate status in the American College of Microbiologists in the subspecialties of Virology and Immunology. He is the only faculty member of the University board certified in both Veterinary Pathology and Veterinary Microbiology. The development of his research expertise has occurred in parallel to his appointments to a number of interdisciplinary graduate programs. Importantly, since 1990 he has been continuously funded by extramural grants including Career Development Awards, R01, and P01 program project grants from the National Institutes of Health and a variety of private agencies. He served as Graduate Studies Chair for the Department of Veterinary Biosciences from 1996 to 2002. In February of 2002 he was appointed Chair of the Department following a national search. In September of 2003, Dr. Lairmore was named Associate Director of Basic Sciences for the OSU Comprehensive Cancer Center (OSUCCC) which consists of over 200 investigators in 13 colleges across campus. As associate director of basic research and member of the senior leadership team for the OSUCCC, Dr. Lairmore facilitates the development of programmatic synergy in basic cancer discovery. He has authored or co-authored over 154 scientific publications in high quality scientific journals (see biographical sketch). His research program has attracted numerous highly qualified predoctoral and postdoctoral scientists and graduate students (see training record) many of which have successfully competed for NIH physician scientist awards. Dr. Lairmore has served as primary advisor for 25 graduate students or postdoctoral fellows. Of these, 18 were veterinarians or veterinary students seeking dual degrees. Among his DVM graduate trainees, 10 earned PhD degrees, 2 earned MS degrees and one was a DVM/PhD postdoctoral fellow. He currently serves as primary advisor for 7 predoctoral (including 5 DVMs or DVM dual degree students) and 1 research scientist (DVM/PhD). Seven of his DVM/PhD or DVM/MS students, concurrently were trained and became board certified in veterinary pathology or microbiology, and 8 were funded by NIH physician scientist awards, NIH NRSAs, or by the Medical Research Council of Canada. In recognition of his contributions to graduate education, the College awarded Dr. Lairmore the Dean's Excellence in Graduate Education Award in 1999. In 2004, he was awarded the Distinguished Scholar Award by the University, one of only six such awards among the ~5000 faculty of the university. In 2005 Dr. Lairmore was recognized as a Fellow of the American Association for the Advancement of Sciences (AAAS). Dr. Lairmore has been appointed as a member of numerous NIH Study Sections as an ad hoc reviewer, served on a variety of United States Public Health Service committees and a member of the Scientific and Technical Review Board for NCRR. He recently completed his role as director of a pre doctoral T-32 training grant restricted to longer term training of veterinary students (1 year)(RR17505).

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More information on Dr. Lairmore's research